International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
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Clostridium difficile Toxin in Adult Inpatients in an Urban Hospital in Malawi: Associations with HIV Status, CD4 Count and Diarrhoea
Nick J. Beeching, Alastair Watson, Paul Paul Roberts, Brian Farragher, Michael B.J. Beadsworth and Alex J. Keeley
Page: 7-9 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
Clostridium difficile Infection (CDI) is the cause of substantial morbidity and mortality in the developed world. However, very little is known about the burden of CDI in sub-Saharan Africa where less antibiotic restriction, high HIV prevalence and greater impact from nosocomial infection mean the potential for a significant disease burden is great. Researchers investigated the prevalence of Clostridium difficile Toxin (CDT), assessing association with HIV, CD4 count and diarrhoea in medical in-patients in Malawi. In 206 patients tested for CDT, 28 (13.6%) were positive. No significant associations were seen with either diarrhoea or HIV. There was a non-statistically significant (p = 0.056) association between CD4 counts of <50 and CDT. The frequency and the clinical implications of CDI in both HIV positive and negative patients in sub-Saharan Africa, requires further assessment.
How to cite this article:
Nick J. Beeching, Alastair Watson, Paul Paul Roberts, Brian Farragher, Michael B.J. Beadsworth and Alex J. Keeley. Clostridium difficile Toxin in Adult Inpatients in an Urban Hospital
in Malawi: Associations with HIV Status, CD4 Count and Diarrhoea.
DOI: https://doi.org/10.36478/ijtmed.2014.7.9
URL: https://www.makhillpublications.co/view-article/1816-3319/ijtmed.2014.7.9