@article{MAKHILLIJTM20149119888,
title = {Clostridium difficile Toxin in Adult Inpatients in an Urban Hospital
in Malawi: Associations with HIV Status, CD4 Count and Diarrhoea},
journal = {International Journal of Tropical Medicine},
volume = {9},
number = {1},
pages = {7-9},
year = {2014},
issn = {1816-3319},
doi = {ijtmed.2014.7.9},
url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2014.7.9},
author = {Michael B.J.,Nick J.,Alastair,Paul Paul,Brian and},
keywords = {sub-Saharan Africa,Clostridum difficile,HIV,diarrhoea,CDI},
abstract = {Clostridium difficile Infection (CDI) is the
cause of substantial morbidity and mortality in the developed world. However,
very little is known about the burden of CDI in sub-Saharan Africa where less
antibiotic restriction, high HIV prevalence and greater impact from nosocomial
infection mean the potential for a significant disease burden is great. Researchers
investigated the prevalence of Clostridium difficile Toxin (CDT), assessing
association with HIV, CD4 count and diarrhoea in medical in-patients in Malawi.
In 206 patients tested for CDT, 28 (13.6%) were positive. No significant associations
were seen with either diarrhoea or HIV. There was a non-statistically significant
(p = 0.056) association between CD4 counts of <50 and CDT. The frequency
and the clinical implications of CDI in both HIV positive and negative patients
in sub-Saharan Africa, requires further assessment.}
}