@article{MAKHILLIJTM20149119888, title = {Clostridium difficile Toxin in Adult Inpatients in an Urban Hospital in Malawi: Associations with HIV Status, CD4 Count and Diarrhoea}, journal = {International Journal of Tropical Medicine}, volume = {9}, number = {1}, pages = {7-9}, year = {2014}, issn = {1816-3319}, doi = {ijtmed.2014.7.9}, url = {https://makhillpublications.co/view-article.php?issn=1816-3319&doi=ijtmed.2014.7.9}, author = {Michael B.J.,Nick J.,Alastair,Paul Paul,Brian and}, keywords = {sub-Saharan Africa,Clostridum difficile,HIV,diarrhoea,CDI}, abstract = {Clostridium difficile Infection (CDI) is the cause of substantial morbidity and mortality in the developed world. However, very little is known about the burden of CDI in sub-Saharan Africa where less antibiotic restriction, high HIV prevalence and greater impact from nosocomial infection mean the potential for a significant disease burden is great. Researchers investigated the prevalence of Clostridium difficile Toxin (CDT), assessing association with HIV, CD4 count and diarrhoea in medical in-patients in Malawi. In 206 patients tested for CDT, 28 (13.6%) were positive. No significant associations were seen with either diarrhoea or HIV. There was a non-statistically significant (p = 0.056) association between CD4 counts of <50 and CDT. The frequency and the clinical implications of CDI in both HIV positive and negative patients in sub-Saharan Africa, requires further assessment.} }