International Journal of Molecular Medicine and Advance Sciences
ISSN: Online 1994-4624ISSN: Print 1813-176x
Abstract
Reactivity responses of autoimmune origin appear a realized series of pathways in the generation of dysfunctional versus homeostatic lymphocyte turnover. Lymphocyte responsiveness would transform to a dysfunctional state in the generation of various subsets of cells as reflected in autoimmune phenomena. It is in terms of a dysfunctionality ranging in scope from primary generation of the lymphocyte subset to subsequent creation of a whole panorama of responsive influences and pathologic lesions that autoimmunity would evolve further as a self-generated reactivity in its own right. Indeed, oligoclonality of antibody production in the cerebrospinal fluid of multiple sclerosis patients would arise as a phenomenon both primarily generated in terms of dysfunctional lymphocyte turnover and as a secondary process in the progression of such primary autoimmune reactivity exposing native myelin epitopes.
How to cite this article:
Lawrence, M. Agius . Dysfunctional Lymphocyte Turnover in Subsequent Self-Generation of Autoimmunity.
DOI: https://doi.org/10.36478/ijmmas.2006.16.22
URL: https://www.makhillpublications.co/view-article/1813-176x/ijmmas.2006.16.22