Lawrence, M. Agius  , 
    Dysfunctional Lymphocyte Turnover in Subsequent Self-Generation of Autoimmunity,
    International Journal of Molecular Medicine and Advance Sciences,
    Volume 2,Issue 1,
    2006,
    Pages 16-22,
    ISSN 1813-176x,
    ijmmas.2006.16.22,
    (https://makhillpublications.co/view-article.php?doi=ijmmas.2006.16.22)
    Abstract: Reactivity responses of autoimmune origin appear a realized series of pathways in the generation of dysfunctional versus homeostatic lymphocyte turnover.  Lymphocyte responsiveness would transform to a dysfunctional state in the generation of various subsets of cells as reflected in autoimmune phenomena. It is in terms of a dysfunctionality ranging in scope from primary generation of the lymphocyte subset to subsequent creation of a whole panorama of responsive influences and pathologic lesions that autoimmunity would evolve further as a self-generated reactivity in its own right.  Indeed, oligoclonality of antibody production in the cerebrospinal fluid of multiple sclerosis patients would arise as a phenomenon both primarily generated in terms of dysfunctional lymphocyte turnover and as a secondary process in the progression of such primary autoimmune reactivity exposing native myelin epitopes.
    Keywords: Self genration;auoimmunity;dysfuntional;lymphocyte