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International Journal of Tropical Medicine

ISSN: Online 1818-779X
ISSN: Print 1816-3319
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A Preliminary Study of Hudu’s Score as a Prognostic Scoring System of Predicting the Risk of Liver Cirrhosis in Patients with Chronic Hepatitis B Infection

Shuaibu Abdullahi Hudu, Mohd Taib Niazlin, Syafinaz Amin Nordin, Soek Siam Tan and Zamberi Sekawi
Page: 17-20 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/ijtmed.2019.17.20

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Abstract

Hepatitis B infection long term prognosis is good in the absence of liver cirrhosis. However, the risk of liver cirrhosis developing in chronic Hepatitis B surface antigen positive varies from 1-5/100 patients per year. This study aimed at developing a novel prognostic scoring system to predict liver cirrhosis in chronic Hepatitis B patients. A total of 82 chronic Hepatitis B patients were recruited retrospectively in a cohort study and their liver Biochemistry, Hepatitis B viral DNA level, viral serology, quantitative Hepatitis B e Antigen (qHBeAg) and development of liver cirrhosis were assessed. The data were included in a multivariate logistic regression analysis based on which this prognostic scoring system was established. A simple scoring system composed of virological and biochemical laboratory parameter was developed to predict liver cirrhosis in chronic Hepatitis B patients. This prognostic score is accurate and reproducible. The prognostic score ranges between 5 and 15. Patients prognostic score of 5 indicates low risk, 10 high risk and 15 very high risk of developing cirrhosis. In conclusion, this study has showed a promising scoring system that can be use in predicting the risk of developing liver cirrhosis in chronic Hepatitis B patients.

How to cite this article:

Shuaibu Abdullahi Hudu, Mohd Taib Niazlin, Syafinaz Amin Nordin, Soek Siam Tan and Zamberi Sekawi. A Preliminary Study of Hudu’s Score as a Prognostic Scoring System of Predicting the Risk of Liver Cirrhosis in Patients with Chronic Hepatitis B Infection.
DOI: https://doi.org/10.36478/ijtmed.2019.17.20
URL: https://www.makhillpublications.co/view-article/1816-3319/ijtmed.2019.17.20