Shuaibu Abdullahi  Hudu, Mohd Taib  Niazlin, Syafinaz Amin  Nordin, Soek Siam  Tan, Zamberi  Sekawi, 
    A Preliminary Study of Hudu’s Score as a Prognostic Scoring System of
Predicting the Risk of Liver Cirrhosis in Patients with
Chronic Hepatitis B Infection,
    International Journal of Tropical Medicine,
    Volume 14,Issue 2,
    2019,
    Pages 17-20,
    ISSN 1816-3319,
    ijtmed.2019.17.20,
    (https://makhillpublications.co/view-article.php?doi=ijtmed.2019.17.20)
    Abstract: Hepatitis B infection long term prognosis is good in the absence of liver cirrhosis. However, the
risk of liver cirrhosis developing in chronic Hepatitis B surface antigen positive varies from 1-5/100
patients per year. This study aimed at developing a novel prognostic scoring system to predict liver cirrhosis
in chronic Hepatitis B patients. A total of 82 chronic Hepatitis B patients were recruited retrospectively in a
cohort study and their liver Biochemistry, Hepatitis B viral DNA level, viral serology, quantitative Hepatitis
B e Antigen (qHBeAg) and development of liver cirrhosis were assessed. The data were included in a
multivariate logistic regression analysis based on which this prognostic scoring system was established. A
simple scoring system composed of virological and biochemical laboratory parameter was developed to predict
liver cirrhosis in chronic Hepatitis B patients. This prognostic score is accurate and reproducible. The
prognostic score ranges between 5 and 15. Patients prognostic score of 5 indicates low risk, 10 high risk and
15 very high risk of developing cirrhosis. In conclusion, this study has showed a promising scoring system that
can be use in predicting the risk of developing liver cirrhosis in chronic Hepatitis B patients.
    Keywords: chronic Hepatitis B patients;prognostic factors;liver cirrhosis;Hepatitis B scoring system;viral serology;Hepatitis B