Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
Taxol has been approved as a powerful broad range anticancer drug, however, the accessibility and pricy of this drug are the main challenges. Thus, fungal source with feasibility of molecular and nutritional manipulations could be the alternative promising platform for bulk production of Taxol. Taxol has been produced by Aspergillus terreus and its chemical identity has been validated from our previous work, however, its biological functionality has not been investigated. Thus, the objective of the current study was to assess the antitumor efficiency of A. terreus extracted Taxol (AT-Taxol) towards EAC solid tumor in male Swiss albino mice. Ehrlich solid tumor cells were inoculated subcutaneously into mice, then the animals were injected with AT-Taxol i.p. and continued for 30 days. AT-Taxol displayed a significant cytotoxic effect against breast cancers (MCF-7) by inhibiting the expression of Antigen KI-67, a nuclear protein associated with the cellular proliferation, comparing to positive controls. As well as, positive control mice showed a dramatic increase of serum ALT, AST activities and liver tissue homogenate lipid peroxidation rate (MDA) accompanied with decline on the level of serum albumin that were ameliorated with AT-Taxol treatment. A plausible reduction on the mice overall body weight, in addition to tumor weight and volume with AT-Taxol treatment comparing to positive controls. From the histo-pathological analysis, AT-Taxol exhibited a significant improvement on different pathological features induced by EAC solid tumor oxidative stress, comparing to positive control mice.
How to cite this article:
Nabila Zein and Ashraf S.A. El-Sayed. Antiproliferative Activity of Aspergillus terreus Taxol Against Ehrlich Solid Tumor In vivo and
In vitro.
DOI: https://doi.org/10.36478/rjpharm.2020.38.43
URL: https://www.makhillpublications.co/view-article/1815-9362/rjpharm.2020.38.43