Research Journal of Biological Sciences
ISSN: Online 1993-6087ISSN: Print 1815-8846
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Atrial Natriuretic Factor Downregulation During Breast Cancer Progression
Biagio Valentino , Giampiero La Rocca , Rita Anzalone , Simona Corrao , Francesca Rappa , Diego Lipari , Alessandro Valentino , Giovanni Peri , Francesco Cappello and Elvira Vittoria Farina-Lipari
Page: 246-250 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
We researched in a series of human breast cancers of different stages the presence and the expression of Atrial Natriuretic Factor (ANF) and Oxytocin (OX), by immunohistochemistry and RT-PCR. We found a reduction of expression of ANF during cancer progression. By contrast, OX resulted lightly expressed by immunohistochemistry and negative at RT-PCR. We hypothesize that ANF could be considered a novel marker to predict breast cancer progression; by contrast, OX expression should be better investigated, to clarify also the putative role of oxytocinases in human breast carcinogenesis.
How to cite this article:
Biagio Valentino , Giampiero La Rocca , Rita Anzalone , Simona Corrao , Francesca Rappa , Diego Lipari , Alessandro Valentino , Giovanni Peri , Francesco Cappello and Elvira Vittoria Farina-Lipari . Atrial Natriuretic Factor Downregulation During Breast Cancer Progression.
DOI: https://doi.org/10.36478/rjbsci.2008.246.250
URL: https://www.makhillpublications.co/view-article/1815-8846/rjbsci.2008.246.250