Biagio Valentino  , Giampiero La Rocca  , Rita Anzalone  , Simona Corrao  , Francesca Rappa  , Diego Lipari  , Alessandro Valentino  , Giovanni Peri  , Francesco Cappello  , Elvira Vittoria Farina-Lipari  , 
    Atrial Natriuretic Factor Downregulation During Breast Cancer Progression,
    Research Journal of Biological Sciences,
    Volume 3,Issue 2,
    2008,
    Pages 246-250,
    ISSN 1815-8846,
    rjbsci.2008.246.250,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2008.246.250)
    Abstract: We researched in a series of human breast cancers of different stages the presence and the expression of Atrial Natriuretic Factor (ANF) and Oxytocin (OX), by immunohistochemistry and RT-PCR. We found a reduction of expression of ANF during cancer progression. By contrast, OX resulted lightly expressed by immunohistochemistry and negative at RT-PCR. We hypothesize that ANF could be considered a novel marker to predict breast cancer progression; by contrast, OX expression should be better investigated, to clarify also the putative role of oxytocinases in human breast carcinogenesis.
    Keywords: Atrial natriuretic factor;oxytocin;breast cancer;carcinogenesis