International Journal of Molecular Medicine and Advance Sciences
ISSN: Online 1994-4624ISSN: Print 1813-176x
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Comparative Evaluation of the Efficacy of Praziquantel (PZQ) and Niridazole/Ambilhar (N/A) in the Treatment of Urinary Schistosomiasis among School Children Examined in Idah and Ibaji Local Government areas (LGAs) of Kogi State, Nigeria
I.A.A. Ejima
Page: 1-8 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
The study was carried out among school children in: Government Day Secondary School and Local Government Education Authority (LGEA) Primary School, Ejule-Ojebe in Ibaji Local Government Area (LGA) and LGEA Primary School, Idah in Idah LGA, Nigeria. It was designed to validate the already established protocol of using Praziquantel (PZQ) as a drug of choice in the treatment of schistosomiasis and other helminths. The cure rate procured by PZQ (66.7%) was significantly higher than that of Niridazole/Ambilhar (N/A) (36.0%) (p<0.05). The validation of the efficacy of praziquantel was established in this study when it was observed in one of the subjects examined whose initial egg-count at week zero was 40 eggs/10 mL urine who failed to turn up for treatment (served as a ‘control’) had egg-excretion increased significantly up to 1,420 eggs/10 mL urine in the 20th week post-treatment when re-examined. Generally, the results showed that there was significant difference (p<0.05) in the percentage cure rate in children placed on PZQ-regimen in the three schools surveyed.
How to cite this article:
I.A.A. Ejima. Comparative Evaluation of the Efficacy of Praziquantel (PZQ) and Niridazole/Ambilhar (N/A) in the Treatment of Urinary Schistosomiasis among School Children Examined in Idah and Ibaji Local Government areas (LGAs) of Kogi State, Nigeria.
DOI: https://doi.org/10.36478/ijmmas.2015.1.8
URL: https://www.makhillpublications.co/view-article/1813-176x/ijmmas.2015.1.8