Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
Abstract
The Spontaneously Diabetic Torii (SDT) rat is a non-obese diabetic model showing various metabolic abnormalities in pre-diabetic stage. In this study, researchers investigated the pancreatic function at young ages, 5 and 7 weeks. At 5 weeks, SDT rats showed glucose intolerance and reduction of Homeostasis Model Assessment (HOMA)-β. At 7 weeks, the insulin content in pancreas was also decreased. Insulinogenic index showed no change at 5 and 7 weeks of age. In conclusion, the pancreatic function in SDT rats was decreased from a young age after weaning and the rat is a useful Animal Model to examine the pathophysiological features of Impaired Glucose Tolerance (IGT).
How to cite this article:
Takeshi Ohta, Masami Shinohara, Takuji Yamamoto and Takahisa Yamada . Pancreatic Abnormalities at a Young Age in Spontaneously Diabetic Torii (SDT) Rats.
DOI: https://doi.org/10.36478/javaa.2012.1322.1326
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2012.1322.1326