Takahisa Yamada  , Takeshi  Ohta, Masami  Shinohara, Takuji Yamamoto  , 
    Pancreatic Abnormalities at a Young Age in Spontaneously Diabetic Torii (SDT) Rats,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 9,
    2012,
    Pages 1322-1326,
    ISSN 1680-5593,
    javaa.2012.1322.1326,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.1322.1326)
    Abstract: The Spontaneously Diabetic Torii (SDT) rat is a non-obese diabetic model showing various metabolic abnormalities in pre-diabetic stage. In this study, researchers investigated the pancreatic function at young ages, 5 and 7 weeks. At 5 weeks, SDT rats showed glucose intolerance and reduction of Homeostasis Model Assessment (HOMA)-β. At 7 weeks, the insulin content in pancreas was also decreased. Insulinogenic index showed no change at 5 and 7 weeks of age. In conclusion, the pancreatic function in SDT rats was decreased from a young age after weaning and the rat is a useful Animal Model to examine the pathophysiological features of Impaired Glucose Tolerance (IGT).
    Keywords: HOMA;IGT;SDT rat;reduction;insulin content;pancreatic