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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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The Effect of Time Interval Between 99mTc -sestamibi Injection and Image Acquisition on Quantitative Data of Gated SPECT Myocardial Perfusion Imaging at Stress and Rest Phases

MD. Alireza Nekooee, Seyed Mohammad Entezarmahdi and Mahdi Haghighatafshar
Page: 683-687 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/rjmsci.2016.683.687

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Abstract

According to several recent studies in favor of delayed 99mTc methoxy-isobutyl-isonitrile (99mTc-MIBI) redistribution, the aim of this study was to find whether different time intervals between 99mTc-MIBI injection and image acquisition could affect quantitative data of gated SPECT Myocardial Perfusion Imaging (MPI). Eighty five patients with moderate pretest probability of coronary artery disease according to "Framingham Risk Score" enrolled in the study. Myocardial perfusion imaging with SPECT was performed on the basis of two-day protocol with stress-phase images obtained at 15/180 and rest-phase images obtained at 60/120 minutes after injection of 666-814 MBq 99mTc-MIBI. Then quantitative data of MPI were obtained and compared at mentioned time intervals. The changes of five parameters including Summed Stress Score (SSS), Summed Motion Score (SMS), Summed Thickening Score (STS), Stroke Volume (SV) and Ejection Fraction (EF) were not significant however; the End Systole Volume (ESV) and End Diastolic Volume (EDV) changes were significant. Also SSS has not significant changes. The results of this study imply that the time interval between the injection and acquisition may affect the detection of endocardial and epicardial surfaces in 99mTc-MIBI myocardial perfusion scanning which afford significant changes in EDV and ESV. While these changes are in a same direction and correlated so, the functional parameters as EF, SV, SMS and STS do not change significantly.

How to cite this article:

MD. Alireza Nekooee, Seyed Mohammad Entezarmahdi and Mahdi Haghighatafshar. The Effect of Time Interval Between 99mTc -sestamibi Injection and Image Acquisition on Quantitative Data of Gated SPECT Myocardial Perfusion Imaging at Stress and Rest Phases.
DOI: https://doi.org/10.36478/rjmsci.2016.683.687
URL: https://www.makhillpublications.co/view-article/1815-9346/rjmsci.2016.683.687