Mahdi  Haghighatafshar, MD.  Alireza Nekooee, Seyed  Mohammad Entezarmahdi, 
    The Effect of Time Interval Between <sup>99m</sup>T<sub>c</sub> -sestamibi Injection and Image Acquisition on Quantitative Data of Gated SPECT Myocardial Perfusion Imaging at Stress and Rest Phases,
    Research Journal of Medical Sciences,
    Volume 10,Issue 6,
    2016,
    Pages 683-687,
    ISSN 1815-9346,
    rjmsci.2016.683.687,
    (https://makhillpublications.co/view-article.php?doi=rjmsci.2016.683.687)
    Abstract: According to several recent studies in favor of delayed <sup>99m</sup>T<sub>c</sub> methoxy-isobutyl-isonitrile (<sup>99m</sup>T<sub>c</sub>-MIBI)
redistribution, the aim of this study was to find whether different time intervals between <sup>99m</sup>T<sub>c</sub>-MIBI injection
and image acquisition could affect quantitative data of gated SPECT Myocardial Perfusion Imaging (MPI).
Eighty five patients with moderate pretest probability of coronary artery disease according to &quot;Framingham Risk
Score&quot; enrolled in the study. Myocardial perfusion imaging with SPECT was performed on the basis of two-day
protocol with stress-phase images obtained at 15/180 and rest-phase images obtained at 60/120 minutes after
injection of 666-814 MBq 99mTc-MIBI. Then quantitative data of MPI were obtained and compared at
mentioned time intervals. The changes of five parameters including Summed Stress Score (SSS), Summed
Motion Score (SMS), Summed Thickening Score (STS), Stroke Volume (SV) and Ejection Fraction (EF) were not
significant however; the End Systole Volume (ESV) and End Diastolic Volume (EDV) changes were significant.
Also SSS has not significant changes. The results of this study imply that the time interval between the
injection and acquisition may affect the detection of endocardial and epicardial surfaces in 99mTc-MIBI
myocardial perfusion scanning which afford significant changes in EDV and ESV. While these changes are in
a same direction and correlated so, the functional parameters as EF, SV, SMS and STS do not change
significantly.
    Keywords: 99mTc-MIBI;scintigraphy;myocardial perfusion;SPECT;quantitative myocardial analysis