Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Tumor patients show alterations of the clotting mechanism by means of a hypercoagulable state. Warfarin’s anti-tumor action was reported in animal cancer models and in human studies with patients already receiving warfarin. An arrest of lung metastases was reported. The mechanism for this anti-tumor action seems to be coagulation-independent, probably involving immune-modulatory mechanisms related to NK function. It would be of great interest to evaluate the hypothesis that warfarin is able to modulate the generation of lymph-node metastases in OSCC by affecting NK receptors in an immune-modulatory manner.
How to cite this article:
Eva-Maria Dietrich. Warfarin Inhibits Tumor Metastasis Through an Immune-Modulatory, Coagulation-Independent Manner That Involves NK Cells: Possible Anti-Tumor Effects in Patients with OSCC?.
DOI: https://doi.org/10.36478/rjmsci.2015.64.66
URL: https://www.makhillpublications.co/view-article/1815-9346/rjmsci.2015.64.66