Eva-Maria  Dietrich, 
    Warfarin Inhibits Tumor Metastasis Through an Immune-Modulatory, Coagulation-Independent Manner That Involves NK Cells: Possible Anti-Tumor Effects in Patients with OSCC?,
    Research Journal of Medical Sciences,
    Volume 9,Issue 3,
    2015,
    Pages 64-66,
    ISSN 1815-9346,
    rjmsci.2015.64.66,
    (https://makhillpublications.co/view-article.php?doi=rjmsci.2015.64.66)
    Abstract: Tumor patients show alterations of the clotting mechanism by means of a hypercoagulable state. Warfarin’s anti-tumor action was reported in animal cancer models and in human studies with patients already receiving warfarin. An arrest of lung metastases was reported. The mechanism for this anti-tumor action seems to be coagulation-independent, probably involving immune-modulatory mechanisms related to NK function. It would be of great interest to evaluate the hypothesis that warfarin is able to modulate the generation of lymph-node metastases in OSCC by affecting NK receptors in an immune-modulatory manner.
    Keywords: Warfarin;OSCC;immune-modulation;killer-cells;natural