Research Journal of Medical Sciences

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Protective Effects of Recombinant Erythropoietin in Ischemia of the Retina: The Role of Mechanisms of Preconditioning

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Abstract

Recombinant erythropoietin in a dose 50 IU kg ^–1 under the condition of half-hour total ischemia of the retina followed by reperfusion showed a pronounced protective action, expressed in the prevention of reduction of the microcirculation, electroretinography amplitude and change of the morphometric values of layers thickness of the retina. The mechanisms of pharmacological preconditioning are important to cardioprotective effects that confirmed by reduction of its effects under the condition of K_ATP channels blockade with glibenclamidum.

How to cite this article:

Anna S. Shabelnikova, Vladimir D. Lutsenko, Mikhail V. Pokrovskii, Anna A. Peresipkina, Mikhail V. Korokin, Oleg S. Gudyrev, Tatyana G. Pokrovskaia, Evgeniya A. Beskhmelnitsyna and Yuri A. Hoshenko. Protective Effects of Recombinant Erythropoietin in Ischemia of the Retina: The Role of Mechanisms of Preconditioning.
DOI: https://doi.org/10.36478/rjmsci.2015.200.203
URL: https://www.makhillpublications.co/view-article/1815-9346/rjmsci.2015.200.203