Research Journal of Medical Sciences

105
Views

1
Downloads

Management and Patient Selection for BRCA Genetic Testing to Identify Women at Increased Risk for Breast and Ovarian Cancers: A Review

Yakup Kumtepe and Kadir Cetinkaya
Page: 83-86 | Received 21 Sep 2022, Published online: 21 Sep 2022

By Research Area

Medicine & Public Health Life Sciences Engineering Mathematics Biomedicine Physics Chemistry Computer Science Earth Sciences Social Sciences Business and Management Psychology Materials Science Economics Education Environment Philosophy Statistics Law Political Science and International Relations Pharmacy Dentistry Energy Linguistics Geography Finance Criminology and Criminal Justice Medicine Cultural and Media Studies History Architecture / Design Literature Biomedical Sciences Religious Studies Education & Language Food Science & Nutrition Public Health

By Volume and Issue

Abstract

Cancer caused by a mutated gene is a hereditary cancer rather than a sporadic cancer. Women who have inherited mutations in the BRCA1 or BRCA2 genes have substantially elevated risks of breast and ovarian cancer. Further genetic risk assessment is recommended for women who have >20-25% chance of having an inherited predisposition to breast or ovarian cancer. Women with harmful mutations in either BRCA1 or BRCA2 have risk of breast cancer that is about 5 times the normal risk and a risk of ovarian cancer that is about 10-30 times normal. Mutation carriers have various options including extensive and regular surveillance, chemoprevention and risk-reducing surgery.

How to cite this article:

Yakup Kumtepe and Kadir Cetinkaya. Management and Patient Selection for BRCA Genetic Testing to Identify Women at Increased Risk for Breast and Ovarian Cancers: A Review.
DOI: https://doi.org/10.36478/rjmsci.2012.83.86
URL: https://www.makhillpublications.co/view-article/1815-9346/rjmsci.2012.83.86