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International Journal of Tropical Medicine

ISSN: Online 1818-779X
ISSN: Print 1816-3319
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Comparison of Prophylactic Effect of Clobazam and Diazepamin Children with Simple Febrile Convulsion (SFC)

Sadeghi Ebrahim, Sadeghimanesh Jafar, Ghazavi Ahad, Abbasi Ezzatollah and Nikibakhsh Ahmadali
Page: 21-23 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/ijtmed.2016.21.23

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Abstract

To compare the effectiveness of intermittent clobazam versus diazepam therapy in preventing the recurrence of febrile seizures and assess adverse effects of each drug. This prospective randomized controlled trial was performed on neurologically normal children aged from 6-60 months with a history of simple febrile seizures and normal electroencephalogram without any evidence of acute central nervous system infection. The patients were randomly prescribed with oral clobazam (36 cases) or diazepam (35 cases) when they developed a febrile disease. They were advised to use the medications during the first 48 h of the onset of fever. All the patients were monitored regarding developing seizure and adverse effects of the drugs. All patients were followed for 12 months. Overall, recurrence of seizures occurred in 1 subject in the clobazam group and in 3 cases in the diazepam group (p = 0.296). The 15 cases in the diazepam group and 7 cases in the clobazam group developed drowsiness and sedation during the follow-up period (p = 0.03). Ataxia occurs in 4 cases of diazepam group and one patient in clobazam group (p = 0.17). Intermittent clobazam therapy seems advantageous to diazepam due to similar efficacy but significantly lower adverse effects such as drowsiness and sedation.

How to cite this article:

Sadeghi Ebrahim, Sadeghimanesh Jafar, Ghazavi Ahad, Abbasi Ezzatollah and Nikibakhsh Ahmadali. Comparison of Prophylactic Effect of Clobazam and Diazepamin Children with Simple Febrile Convulsion (SFC).
DOI: https://doi.org/10.36478/ijtmed.2016.21.23
URL: https://www.makhillpublications.co/view-article/1816-3319/ijtmed.2016.21.23