International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Dengue fever the most common arthropod‐borne disease, is transmitted by mosquitoes of the Aedes family. Liver damage caused by dengue can range from moderate (high transaminase levels) to severe (hepatocyte destruction). The study's goals were to (1) determine how often hepatic dysfunction occurs in dengue patients and (2) analyze the relationship between hepatic dysfunction severity and illness severity. Methods: One hundred patients with confirmed dengue serology who were admitted to the general medicine department of the Kalinga Institute of Medical Sciences in Bhubaneswar participated in this retrospective cross‐sectional observational research. Several laboratory values were obtained in addition to the patient’s demographic data. Aspartate aminotransferase (ALP), total and direct bilirubin, serum levels of albumin and globulin, complete blood count, serum glutamic‐oxaloacetic transaminase (SGOT), serum glutamic‐pyruvic transaminase (SGPT) and clinical symptoms were among the data that were measured. In accordance with the categorization that was established by the World Health Organization in 2009, two distinct groups of patients were identified those who were suffering from severe dengue and those who had dengue with or without warning signals. After doing a One‐Way Analysis of Variance (ANOVA) to compare multiple means across illness severity the post‐hoc analysis was based on the difference that was found to be the least significant. To find out how transaminases and platelet counts were related, we employed Pearson’s correlation coefficient. All of the analyses made use of 95% confidence intervals and p>0.05. Elevated SGOT levels were seen in 69% of patients with dengue without warning symptoms, 81% of patients with warning indications and 94% of patients with severe dengue. Serum glutathione concentrations were elevated in 94% of severe dengue patients, 55% of patients with warning indications of the disease and 45% of patients with no symptoms at all. When SGOT and SGPT levels were high, more patients experienced bleeding symptoms. There was a substantial increase (p<0.0001) in hypoalbuminemia (53% of cases) and A:G ratio reversal (30%) in cases of severe dengue. A negative correlation (p<0.0001) was seen between platelet count and SGOT and SGPT levels. Liver damage was suggested by elevated transaminase levels in 77% of dengue patients. A higher level of SGOT and SGPT indicates a more severe case of dengue. It is common for dengue fever to cause damage to the liver, hence, biochemical markers such transaminitis, hypoalbuminemia and A:G ratio reversal should be applied in order to diagnose and monitor liver dysfunction in dengue patients.
How to cite this article:
Abhishek Kumar Verma, Modugula S. Naga Swetha, Dibyalochan Praharaj and Anil Chandra Anand. Spectrum of Liver Dysfunction and the Indicators of Severe Disease in Dengue Patients.
DOI: https://doi.org/10.36478/10.59218/makijtm.2023.3.64.68
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2023.3.64.68