International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Dengue fever, a globally prevalent viral hemorrhagic disease caused by the Flavivirus genus, poses a substantial public health threat. The disease, transmitted by Aedes mosquitoes, affects millions globally, with diverse clinical manifestations. Diagnosis relies on detecting NS1 antigen and IgM antibodies but recent studies propose serum ferritin as a potential diagnostic marker with prognostic implications. To assess serum ferritin's diagnostic efficacy in dengue and explore its correlation with disease severity and patient outcomes. A hospital‐based prospective study involving 49 Dengue‐positive cases was conducted, focusing on NS1‐positive or IgM‐positive patients. Serum ferritin levels were measured on admission (Day 1) and Day 5. Statistical analysis employed Jamovi software, with a p<0.05 considered significant. Among 49 Denguepositive cases the average age was 47.4±20.9 for females and 29.4±13.0 for males. Day 1 Ferritin levels ranged predominantly from 1500‐>1650 ng mLG1, while Day 5 Ferritin consistently fell below 500 ng mLG1. A 12.2% mortality rate was observed having a trend of higher values of ferritin levels on Day 5, emphasizing the severity of the disease. The study reveals significant age disparities and a concerning mortality rate, emphasizing the need for nuanced interventions. Day 1 and Day 5 Ferritin dynamics offer insights into the inflammatory response, potentially aiding in predicting disease severity and guiding clinical decisions. Tailored interventions and ongoing research are essential for Dengue management, emphasizing age‐specific vulnerabilities and the integration of Ferritin monitoring in routine assessments for timely adjustments. Continuous surveillance is recommended for early outbreak detection.
How to cite this article:
Vivek Paul Chowdhury, M.D. Rizwan Ul Haque, Subham Dey, Satyam Kundu and Kausik Munsi. Dengue Diagnosis Demystified: The Significance of Serum Ferritin.
DOI: https://doi.org/10.36478/10.59218/makijtm.2023.3.52.56
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2023.3.52.56