International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
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Abstract
Type II diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and impaired insulin secretion. First‐degree relatives (FDRs) of T2DM patients are at higher risk of developing insulin resistance and T2DM. Omentin‐1 an adipokine, plays a role in insulin sensitivity and glucose metabolism. This study aimed to evaluate serum omentin‐1 levels in normoglycemic FDRs and its correlation with various parameters. This cross‐sectional study included 96 participants 48 normoglycemic FDRs (cases) and 48 age and sex‐matched controls. Cases were further divided into normal‐weight and obese/overweight subgroups based on body mass index (BMI) and waist circumference (WC). Serum omentin‐1 levels, physical parameters (BMI and WC) and biochemical parameters (fasting blood sugar (FBS) total cholesterol (TC) triglycerides (TG) were measured. Statistical analyses included t‐tests, Spearman’s rank correlation and Mann‐Whitney u‐test. Serum omentin‐1 levels were significantly lower in FDRs compared to controls (p<0.001). Among FDRs, omentin‐1 levels were lower in the obese/overweight subgroup compared to the normalweight subgroup (p = 0.016). There was a significant negative correlation between omentin‐1 levels and BMI in FDRs (rs = ‐0.38, p<0.001). TC levels negatively correlated with omentin‐1 in FDRs (rs = ‐0.219, p = 0.032). No significant correlation was found between omentin‐1 levels and FBS, WC or TG in any group. Gender did not significantly affect omentin‐1 levels. This study reveals reduced serum omentin‐1 levels in normoglycemic FDRs, especially in those who are obese/overweight, suggesting a potential role for omentin‐1 in the patho‐physiology of T2DM. Omentin‐1 may play a role in glucose metabolism and insulin sensitivity. Strategies to maintain healthy body weight and promote physical activity could help improve omentin‐1 levels and reduce the risk of T2DM in FDRs. Type II diabetes mellitus, omentin‐1, first‐degree relatives, insulin resistance, obesity, glucose metabolism, adipokines.
How to cite this article:
M. Priyanka, K. Kalyan Kumar, P. Srilakshmi and A. S. Jasmin. Reduced Omentin‐1 Concentrations in the Serum of Normoglycemic First‐Degree Relatives of
Individuals with Type 2 Diabetes.
DOI: https://doi.org/10.36478/10.59218/makijtm.2023.3.30.34
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2023.3.30.34