International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Liver plays a vital role in lipid metabolism hence chronic liver disease is often associated with impaired lipid metabolism. Cirrhosis of liver is a chronic condition of hepatocellular failure due to different etiology, leads to increases the morbidity and mortality. The aim of the study is to assess the degree of alteration of serum lipid profile in alcoholic cirrhotic patients and also detect its relationship with the chronic liver disease. This cross‐sectional study was conducted in a tertiary care teaching hospital of central India. A total of 320 (160 liver cirrhosis (cases) and 160 healthy individuals (controls) were enrolled. Detailed history taking, clinical examination and relevant investigations was done Serum lipid profile (total cholesterol, low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) cholesterol and triglyceride) was recorded for each case and control. Most of the chronic liver disease patients were between 41‐50 years of age, mean age of the patients was 45.73+8.23 years. Majority of them (80%) were male. Alcoholism was the most common cause of liver cirrhosis. Patients among the ‘Class B’ have high Child Pugh score. There was a significant decrease in total cholesterol, triglyceride, serum HDL and LDL cholesterol in liver cirrhosis group as compared with the control group (p<0.05). lipid profiles were found to be significantly decreased in patients with liver cirrhosis. Screening for dyslipidemia may be an important tool to initiate appropriate therapy in liver cirrhosis patients.
How to cite this article:
Shashank Tyagi, Nandini Shukla, Poorva Parihar and Amrita Vamne. Study of Serum Lipid Profile in Patients with Chronic Liver Disease and Its Correlation.
DOI: https://doi.org/10.36478/10.59218/makijtm.2023.2.67.71
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2023.2.67.71