International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Patients with chronic renal failure CRF suffer from lipid abnormalities, changes in the level of oxidative stress status and hyperhomocysteine, and these accelerate the development of atherosclerosis. Hence this study was undertaken to know the risk of cardiovascular morbidity in CRF patients. A case‐control study was carried out in department of Nephrology, NIMS, Jaipur with 50 patients and 50 healthy volunteers of both sexes aged 20‐59 years. Test for serum lipid profile, urea creatinine, FBS, PPBS, total protein and albumin were carried out in all the cases and controls. The results were analyzed and compared with the controls using Microsoft Excel software. The levels of serum TG, TC, LDL‐C, VLDL‐C, TC/HDL‐C and LDL‐C/HDL‐C ratio were significantly increased and HDL‐C was significantly decreased in cases when compared to controls. Serum TG, TC, VLDL‐C and HDL‐C are significantly increased in conservatively managed patients than hemodialysis patients. Serum MDA was significantly increased and SOD was significantly decreased in cases when compared to controls. These changes were more pronounced in hemodialysis patients when compared to conservatively managed patients. We conclude that lipid abnormalities in CRF accelerates the progression of the renal failure and predisposes to atherosclerosis, hence it is worthwhile detecting and treating hyperlipidemia in CRF patients early on. Chronic kidney disease, hemodialysis and lipid prole.
How to cite this article:
Prateek Tripathi. Lipid Profile, Oxidative Stress and Homocysteine in Chronic Renal Failure.
DOI: https://doi.org/10.36478/10.59218/makijtm.2020.113.117
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2020.113.117