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International Journal of Tropical Medicine

ISSN: Online 1818-779X
ISSN: Print 1816-3319
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Some Critical Presentations of Sickle Cell Disease (SCD) Crisis Among the Pediatric Population from India: A Rare Case Series

S.K. Aizuddin, Deblina Patra, Aditya Kayal, Sumedha Bhattacharyya and Sumanta Laha
Page: 88-91 | Received 20 Dec 2024, Accepted 08 Feb 2025, Published online: 19 Feb 2025

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https://doi.org/10.36478/10.36478/makijtm.2025.1.88.91

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Abstract

Sickle Cell Disease(SCD) is a group of inherited RBC disorders caused by abnormal hemoglobin polymerization leading to erythrocyte rigidity and vaso occlusion. Acute painful episodes and dactylitis (vaso‐occlusive crises), acute chest syndrome, sepsis, hemolytic episodes, splenic sequestration, aplastic crisis, stroke and priapism are some of its complications. In this case series, we have reported 3 children from rural setups in India, presenting with various crises like an aplastic crisis, vaso‐occlusive crisis and hyper hemolytic crisis. The first case was a case of scrub typhus with parvovirus B19‐induced aplastic crisis in preexisting sickle cell disease, who had a triad of SCD, fever and reticulocytopenia. The second case was a classical vaso‐occlusive crisis leading to acute chest syndrome with a chest X‐ray revealing a consolidation and small pleural effusion in the left lower lobe. 3rd case was diagnosed as hyper hemolytic syndrome after blood transfusion in SCD and treated with high‐dose intravenous methylprednisolone and IVIG along with other supportive measures. Prompt recognition of symptoms, a high index of suspicion and aggressive management can prevent adverse outcomes in these critical cases of SCD.

How to cite this article:

S.K. Aizuddin, Deblina Patra, Aditya Kayal, Sumedha Bhattacharyya and Sumanta Laha. Some Critical Presentations of Sickle Cell Disease (SCD) Crisis Among the Pediatric Population from India: A Rare Case Series.
DOI: https://doi.org/10.36478/10.36478/makijtm.2025.1.88.91
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2025.1.88.91