International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
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Abstract
Acute infections of the nervous system are among the most important problems in medicine because early recognition, efficient decision‐making and rapid institution of therapy is lifesaving. Meningitis is causes by infectious and non‐infectious etiologies. Infectious etiology can be bacterial, viral, fungal, protozoal organism. Bacterial meningitis is a life‐threatening neurological condition and needs prompt parenteral antibiotics, compared to viral and aseptic meningitis which carries relatively better outcome. Many enzymes are known to be present in abundance in the nervous system. Meningitis disturbs the blood brain barrier (BBB) and is expected to cause rise in enzymatic activity. Enzymatic study (CSF LDH) is a better sensitive parameter in diagnosis of various types of meningitis when used along with conventional tests such as protein glucose and white cell count. Present study was aimed to study lactate dehydrogenase and creatine kinase in cerebrospinal fluid in different types of meningitis. 100 patients presenting with history, characteristic clinical signs and symptoms of meningitis are taken into the study. History was taken clinical examination was done and the relevant investigations are done in the selected patients. Mean CSF LDH and CK values are elevated from the baseline. The elevation of LDH was more in bacterial meningitis(267.9U/L) followed by cryptococcal(228.5U/L), tubercular(177.1U/L) and viral meningitis(124.8U/L). The elevation of CK was more in bacterial meningitis(90.3U/L) followed by cryptococcal (77.6U/L), tubercular(63.8U/L) and viral meningitis(50.1U/L) and this is statistically significant (P<0.001). There was a strong positive correlation between the serum and CSF level of CK and LDH .This is statistically significant (P<0.001) . Estimation of CSF LDH, CK will help in the diagnosis of meningitis along with other parameters like CSF cell count, glucose, proteins.
How to cite this article:
K.S. Supritha, Akshay Biskop, Mahesh Koulagi, K. Kiran and Ahemer Siddiqui. A Study of Lactate Dehydrogenase and Creatine Kinase in Cerebrospinal Fluid in Different Types of Meningitis.
DOI: https://doi.org/10.36478/10.36478/makijtm.2025.1.71.75
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2025.1.71.75