International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
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Abstract
The Corona virus disease 2019 (COVID‐19) is characterized by acute clinical pathologies, including various coagulopathies that may be accompanied by hyper coagulation and platelet hyper activation. In this study, we collected and analyzed plasma samples from Long covid infection patients and healthy individuals and found out that the former has significant microclots in their blood compared to normal individuals. Also, other obvious variations between long‐covid patient samples and normal ones were noted which is respiratory failure and hypoxia. People getting affected with covid‐19 may or may not have life threatening prothrombotic problems. The technique of Fluorescence microscopy using thioflavin dye (ThT) was employed to study plasma samples obtained from long covid patients and healthy individuals. Plasma sample from both long covid patients and healthy individuals were found to contain microclots but long covid‐19 patients had severe microclots. This may be due to ineffective lysis of the insoluble fibrin clot due to deviations from the normally functioning fibrinolytic system brought about by the dysregulated inflammatory molecules which inhibit the fibrinolytic system including up regulation of plasminogen activator inhibitor‐1(PAI‐1) which interferes with TPA function and results in dysregulated coagulation system. Detection of microclots can possibly help to identify patients with long COVID infection who might benefit from anticoagulant therapy. In addition to microclot formation, significant platelet dysfunction and a systemic endothelilitis drive systemic cellular hypoxia.
How to cite this article:
Lathan Kumar, Uma Lakshmi, K.S. Sridharan, Ravishankar , Anand and Sri Gayathri Shanmugam. Identification of Microclot by Fluorescent Microscopy in Patients with Long Covid‐19 Infection.
DOI: https://doi.org/10.36478/10.36478/makijtm.2025.1.7.11
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2025.1.7.11