International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
The study aims to provide a detailed description of how the cerebellar cortex develops and matures during fetal life mainly the Purkinje cells. The age range of the fetuses was ranging from 16‐36 weeks of Gestation. The objective of this study was to provide a detailed description of the histogenesis of the human cerebellar cortex during prenatal development. The fetuses were categorized into five age groups based on gestation and then processed histologically using 10% formalin fixation. Around 25 weeks, Purkinje cells began to differentiate and by 32‐34 weeks, they formed a single row with characteristic morphology. A comprehensive understanding of cerebellar anatomy and Purkinje cell histogenesis is crucial for elucidating the complex mechanisms underlying various neurological and developmental disorders, including, Cerebellar ataxia.
How to cite this article:
V. Shanmugapriya, T. Sivakami and G. Subbulakshmi. Developmental Origin of Purkinje Cells in Human Fetal Cerebellum: A Descriptive Study on Cerebellar Histogenesis.
DOI: https://doi.org/10.36478/10.36478/makijtm.2025.1.24.29
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2025.1.24.29