International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
The objective of this study was to determine the effectiveness of topical 5‐Fluorouracil in combination with microneedling for the treatment of stable vitiligo in patients aged 18‐60 years. A randomized study was conducted at Saraswati Institute of Medical College Hapur UP, India, involving 19 participants with stable vitiligo. The participants, aged <18 years, were included in the study. The study included Fitzpatrick skin types II‐V and the absence of adverse condition for microneedling. Participants underwent microneedling sessions weekly, followed by the application of 5‐FU solution on treated patches. Treatment responses were evaluated using a G score on a four‐point scale. Data were analysed using SPSS software and the efficacy of treatment was assessed through descriptive statistics and Wilcoxon signed‐rank tests. The study found that 52.5% of patients achieved an excellent response (G4) after treatment, with acral lesions showing the highest efficacy (42.1% achieving G4). Overall, 21% of patients exhibited poor outcomes (G1), indicating variability in treatment responses. The chronic nature of the disease was evident, with 36.8% of participants having had vitiligo for over ten years. The findings suggested that microneedling combined with 5‐FU is an effective treatment for stable vitiligo, particularly in acral areas. The variability in responses highlights the necessity for personalized treatment plans tailored to individual patient characteristics and lesion locations. Continued research is essential to refine therapeutic strategies and improve management of vitiligo, ultimately enhancing the quality of life for affected individuals.
How to cite this article:
Megha Sharma and Prashant Kumar Yadav. Role of Topical 5 Fluorouracil with Micro needling in Stable Vitiligo.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.4.86.91
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.4.86.91