International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Type‐2 diabetes mellitus (T2DM) is a complex metabolic disorder, with unclear roles of micronutrients like vitamin D and calcium in its pathogenesis. To evaluate and compare vitamin D and calcium levels in serum of T2DM cases and healthy controls and investigate their associations with plasma glucose levels in T2DM by analyzing correlations. This hospital‐based, observational, analytic cross‐sectional study included 122 T2DM patients and 122 age‐and sex‐matched controls. FPG, PPPG, serum vitamin D and calcium levels were measured. Statistical analyses were performed using SPSS® version 28.0.0, with Pearson’s correlation and unpaired t‐tests. A p‐value<0.05 was considered statistically significant and p<0.001 highly significant. FPG (170±52.91 mg/dl vs. 75.88±15.8 mg/dl) and PPPG (216±39.19 mg/dl vs. 111±14 mg/dl) were significantly higher in T2DM (p=0.0001). Vitamin D levels were significantly lower in T2DM (24.23±10.60 ng/ml vs. 28.5±10.23 ng/ml, p=0.038), with a negative correlation with FPG (r=‐0.375, p=0.0002). Calcium levels were lower but not statistically significant (9.1±1.61 mg/dl vs. 9.59±2.36 mg/dl, p=0.052) and showed a negative correlation with FPG (r=‐0.205, p=0.023), which was statistically significant. A positive correlation between calcium and vitamin D (r=0.344, p=0.000) was statistically highly significant. Deficiencies in vitamin D and calcium may contribute to T2DM development and progression. Vitamin D deficiency potentially contribute to lower calcium levels in T2DM patients. Adequate vitamin D and calcium could support glucose homeostasis and their laboratory measurements may play a critical role in prevention and management of T2DM.
How to cite this article:
Surbhi Chaudhary, Shreya Nigoskar, Ravi Ramkishan Yadav and Harjeet Singh. Vitamin D and Calcium in Type‐2 Diabetes Mellitus: An Analytic Cross‐Sectional Study.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.4.214.219
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.4.214.219