International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
This study aimed to utilize biomarkers present in cord blood to predict the severity and prognosis of birth‐related hypoxia. The investigation focused on the correlation between the severity of hypoxic‐ischemic encephalopathy (HIE), as assessed by the Thompson score and cord blood markers including lactate dehydrogenates (LDH), lactate and uric acid. Additionally, the relationship between these cord blood markers and clinical outcomes, as well as their association with high‐risk pregnancies, was examined. A total of 120 neonates who met the specified inclusion and exclusion criteria were enrolled in the study. Cord blood samples were collected and analyzed for LDH, lactate and uric acid levels. Following resuscitation, the infants were transferred to the neonatal intensive care unit (NICU), where HIE staging was performed using the Thompson score within the first 24 hours of life, alongside the documentation of other relevant clinical details in a pre‐designed proforma. The analysis revealed that neonates classified as stage 2 and stage 3 of HIE exhibited significantly elevated levels of LDH (with a sensitivity of 74.82% and specificity of 80.42%), lactate (sensitivity of 69.12% and specificity of 80.9%) and uric acid (sensitivity of 74.32% and specificity of 84.32%). HIE remains a critical contributor to morbidity and mortality in newborns. The concurrent measurement of LDH, lactate and uric acid levels presents a promising diagnostic approach for assessing the severity of HIE prior to the onset of clinical symptoms, thereby facilitating timely interventions aimed at reducing associated morbidity and mortality.
How to cite this article:
Rajiv Kumar, Nagesh Sali and John Basha Shaik. Study on Effects of Cord Blood PH and Biochemical Markers on Severity of Perinatal Asphyxia in a Term Neonate.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.4.211.213
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.4.211.213