International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
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How Well 0.1% Adapalene with 2.5% Benzoyl Peroxide Treats Mild to Moderate Acne Vulgaris in North India Compared to 0.1% Adapalene with 1% Clindamycin
Manoj Kumar, Deepak Sharma, Prashant Harit, Nikhil Rajak, Naresh Jyoti, Paulina Rose Choudhary and Rajveer Singh
Page: 104-110 | Received 20 Aug 2024, Published online: 22 Oct 2024
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Abstract
The aim of the present study is to determine how well 0.1% Adapalene with 2.5% Benzoyl Peroxide treats mild to moderate acne vulgaris in North India compared to 0.1% adapalene with 1% Clindamycin? The study protocol was approved by the Institutional Ethics Committee. Subsequently, the study was initiated. This Interventional, Comparative study included subjects aged 12‐35 years clinically diagnosed with acne vulgaris in adolescent patients attending the Department of Dermatology at Adesh Medical College and Hospital, Shahabad Mohri, Haryana, India. When the subject was under 18 years of age and below, we obtained special pediatric informed consent from the parent. No significant difference was found between baseline lesions and lesions at the end of 2 weeks (p>0.05) in the two groups, but a statistically significant difference was noted in lesions at the end of 4 weeks and 6 weeks (p<0.05) in the inflammatory lesions. The difference in visits was statistically significant (p<0.0001) in both groups. Statistically, there was a difference in total lesions between the two groups at different visits (p<0.05), but no significant difference between the groups at different visits (p>0.05). Adapalene exhibits comparable effectiveness and is relatively well tolerated in comparison to the combination of benzoyl peroxide and clindamycin. Therefore, adapalene can be used independently to treat mild to moderate acne vulgaris, similar to the benzoyl peroxide‐clindamycin approach. Severe inflammatory lesions of acne can be topically treated with a combination of clindamycin and adapalene, or benzoyl peroxide and clindamycin in conjunction with systemic therapy.
How to cite this article:
Manoj Kumar, Deepak Sharma, Prashant Harit, Nikhil Rajak, Naresh Jyoti, Paulina Rose Choudhary and Rajveer Singh. How Well 0.1% Adapalene with 2.5% Benzoyl Peroxide Treats Mild to Moderate Acne Vulgaris in North India Compared to 0.1% Adapalene with 1% Clindamycin.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.4.104.110
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.4.104.110