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International Journal of Tropical Medicine

ISSN: Online 1818-779X
ISSN: Print 1816-3319
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A Study on Prevalence of Vitamin B12 Deficiency in Patients with Pancytopenia in Western Part of UP State of India

Vinod Kumar Tyagi, Jyoti Batra, Vidushi Tyagi, Samiya Faiz, Arvind Kumar and Nishant Tayal
Page: 130-133 | Received 15 Jun 2024, Published online: 27 Jul 2024

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https://doi.org/10.36478/10.36478/makijtm.2024.3.130.133

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Abstract

A hematologic disorder called pancytopenia is defined by a reduction in all three peripheral blood cell lineages. Less than 12 g/dL of hemoglobin in women and 13 g/dL in males, less than 150,000 platelets per mcL or and an absolute neutrophil count of less than 1800 per milliliter are the characteristics that define it. Since pancytopenia can manifest in a variety of ways, a thorough assessment is carried out to determine its underlying cause. Study conducted prospectively in 50 patients of pancytopenia with age 18 years and above, who were presented to Department of Medicine in L.L.R.M MEDICAL COLLEGE, MEERUT during the period from May 2022 to May 2024. A complete clinical history and examination was carried out. They were evaluated for complete blood count with peripheral smear, liver function test, renal function test, vitamin B12 level and bone marrow examination in all patients. The etiological causes of pancytopenia were recorded as megaloblastic anaemia (84%)and aplastic anemia (16%).Most common presenting symptoms are pallor and easy fatiguability. About 52%, have hyper segmented neutrophils,46% of the population have macrocytosis, 44% of individuals have Macrovalocytosis and 26% of the subjects exhibited a dimorphic picture. About 78% of cases have hypercellularity and all patients with vitamin B12 deficiency improved after treatment with vitamin B12 supplement. Pancytopenia is not an uncommon clinical entity and has various etiologies. Most common cause of pancytopenia was B12 deficiency and most common symptoms and signs were easy fatiguability and pallor. Treatment for vitamin B12 deficiency was shown to improve hematological parameters.

How to cite this article:

Vinod Kumar Tyagi, Jyoti Batra, Vidushi Tyagi, Samiya Faiz, Arvind Kumar and Nishant Tayal. A Study on Prevalence of Vitamin B12 Deficiency in Patients with Pancytopenia in Western Part of UP State of India.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.3.130.133
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.3.130.133