International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Recent evidence suggests that arterial stiffness has independent predictive valve for cardiovascular events. A wealth of epidemiological data support a relationship between hypertension and atherosclerosis risk, and excessive clinical trial evidence has established that pharmacologic treatment of hypertension can reduce the risk of stroke, heart failure and CHD events. to evaluate the effect of. valsartan in acute and sub‐acute models of inflammation in male Wistar rats. Methods: Animals were divided into five groups (n=6). In acute inflammation, control group received 0.5 ml of 1 % gum acacia suspension, while the other groups received therapeutic equivalent doses of one of the drugs, aspirin, valsartan. Valsartan was administered two hrs prior to the carrageenan injection. The rat paw volume was measured with the help of a plethysmograph at regular intervals and percentage inhibition of edema in various treated groups was calculated. Valsartan showed significant anti‐inflammatory effect in acute as well as sub‐acute models of inflammation when compared to control. Anti‐inflammatory effect of valsartan is comparable to aspirin in acute model of inflammation. In sub‐acute model of inflammation, valsartan was found to have anti‐inflammatory effect comparable to aspirin Valsartan have shown significant anti‐inflammatory activity in acute and sub‐acute models of inflammation. In acute model of inflammation, valsartan have shown significant anti‐inflammatory effect when compared to control and their effect was comparable to aspirin.
How to cite this article:
Somnath M. Matule, Kapil Sangappa Dhumure and Anil Hogade. Effect of Valsartan on Acute And Sub‐Acute Models of Inflammation in Male Wistar Rats: An Experimental Study.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.3.121.125
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.3.121.125