International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Hepatitis C virus (HCV) is a persistent infective condition that mostly affects the liver. While HCV primarily causes hepatitis, many chronic HCV patients experience extra hepatic involvement during their disease. Chronic HCV infection can lead to many forms of renal disorders. HCV infection has been associated to a range of histopathological types of kidney diseases, including membra no proliferative glomerulonephritis (MPGN), membranous nephropathy, fibrillary/immunotactoid glomerulopathy, focal segmental glomerulosclerosis, IgA nephropathy, renal thrombotic micro an giopathy, interstitial nephritis and vasculitic renal involvement. The most common kind of HCV‐related glomerulonephritis is membrane proliferative glomerulonephritis (MPGN), which is linked to type II cryoglobulinemia. Direct‐acting antiviral treatments have significantly improved the treatment of HCV infection, leading to faster viral clearance. Patients with HCV with kidney dysfunction can be managed using a combination of antiviral medications, immunosuppressant, plasm apheresis and monoclonal antibodies. If antiviral therapy alone does not result in renal disease remission, adding B‐cell depleting drugs can help prevent pathogenic antibodies from forming. Immunosuppressive treatments, including steroids, alkylating drugs and plasma exchanges, can effectively decrease immune‐complex‐driven inflammation. However, their propensity to promote HCV replication and aggravate liver disease is a significant drawback.
How to cite this article:
Rahul Ade, Hema Manvi Koneru and Avula Surya Teja. Hepatitis C Causing Membranous Nephropathy.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.3.110.115
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.3.110.115