International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
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A Retrospective Study on Antibiotic Sensitivity Pattern of Pathogens Isolated from Blood Culture in Cases of Late‐Onset Neonatal Sepsis at a Neonatal Intensive Care Unit
Adesh Patidar, Girish Ramesh Rane, Shubhangam Sharma and Sanjay Singh
Page: 107-110 | Received 10 Apr 2024, Published online: 19 May 2024
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Abstract
Despite significant advancements in neonatal intensive care, late‐onset neonatal sepsis (LONS) remains a substantial contributor to neonatal morbidity and mortality. The etiological agents responsible for LONS and their susceptibilities to antibiotics vary regionally, influencing the selection of empiric antibiotic therapy in suspected cases of sepsis. This study aimed to ascertain the drug sensitivity profiles of commonly isolated pathogens in cases of LONS. A Retrospective analysis was performed on blood culture sensitivity data from neonates admitted and managed for LONS at the neonatal intensive care unit of an Indian Hospital over a one‐year period. A total of 123 neonates were admitted with suspected LONS, comprising 79 males and 44 females. The microbial analysis revealed Gram‐positive organisms, specifically coagulase‐negative staphylococci (CoNS), as the primary cause of culture‐positive cases. Klebsiella pneumoniae was the most prevalent Gram‐negative pathogen, ranking second after CoNS. Other pathogens included Pseudomonas, Acinetobacter, enterococci, Citrobacter, collectively known as the ESKAPE group. Notably, all isolates exhibited resistance to penicillin, while ampicillin and gentamicin displayed the lowest efficacy against these bacteria. Moderate sensitivity was observed with third‐generation cephalosporins (e.g., ceftriaxone, cefotaxime), whereas meropenem, imipenem and linezolid demonstrated the highest sensitivity. Our findings indicate an upward trend in resistance to commonly prescribed first‐line empiric antibiotics like ampicillin and gentamicin. Therefore, regular surveillance of antibiotic susceptibility is crucial for guiding appropriate empiric antibiotic selection.
How to cite this article:
Adesh Patidar, Girish Ramesh Rane, Shubhangam Sharma and Sanjay Singh. A Retrospective Study on Antibiotic Sensitivity Pattern of Pathogens Isolated from Blood Culture in Cases of Late‐Onset Neonatal Sepsis at a Neonatal Intensive Care Unit.
DOI: https://doi.org/10.36478/10.36478/makijtm.2024.2.107.110
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2024.2.107.110