International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
The present study was conducted to understand the role of NIPPV in patients with Type II Respiratory failure. The sample size was 40. In our study cohort, the most common clinical diagnosis included COPD exacerbation, 90% (36/40) with or without associated co‐morbidities. The Borg dyspnoea score improved from 5 at baseline to 1.4±0.07 at discharge. (p <0.0001). The mean respiratory rate dropped from 34.8±4.4 before NIV to 13.82±1.96 (p<0.0001) at discharge. The mean pH changed from 7.29±0.02 at baseline to 7.4±0.03 at discharge(p<0.0001).There was also a marked improvement in mean PaCO2 and PaO2 which changed from, 67.3±5.61, 54.6±8.85 at baseline to 50.02±4.08, 75.1±9.71 at the time of discharge respectively(p<0.0001 for both parameters).Respiratory rate at baseline was significantly higher in the patients who failed to respond to NIV and there was a significant improvement in the clinical and blood gas parameters within the 1st of NIV in the successful group whereas no such improvement was observed in the failure group. In the present study NIPPV was successful in 34 patients (85%) and 6 patients (15%) failed to respond and required intubation. Of them, 2 patients did not consent and left against medical advice. 4 were intubated 2 survived and 2 eventually expired. No mortality was observed in the patients improved and continued on NIPPV. The mean IPAP used in the present study was 16.5±0.9 and mean EPAP used was 5.2±0.52. NIPPV was used for an average of 38.5±13 hrs. The incidence of complications in the present study was 10% which included aspiration pneumonia(2.5%), irritation of eyes (5%) and dryness of mouth (2.5%).The mean duration of hospital stay in the present study was 10.32±3.46 days. Our results strongly support and encourage the use of NIV as a first line ventilatory management in patients with respiratory failure due to acute exacerbations of COPD and the present study showed improvement in both the patients of Kyphoscoliosis and obstructive sleep apnea when put on NIPPV. Thus, NIPPV may be beneficial in these patients when they present with acute on‐chronic respiratory failure.
How to cite this article:
G. Venkata Lakshmi, Vuppu Himavarsh and Prathipati Pullarao. A Study of Role of Noninvasive Ventilation in Patients with Type ii Respiratory Failure.
DOI: https://doi.org/10.36478/10.36478/makijtm.2022.4.50.55
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2022.4.50.55