Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
The study of in vivo antiplasmodial activity and acute toxicity of the active fraction of Garcinia parvifolia Miq has been conducted. The fraction was obtained by maceration of n-hexane extract with methanol. A standard 4-day test on P. berghei infected Swiss mice was used to evaluate the in vivo antiplasmodial activity after an oral administration of the fraction in series dose of 25-200 mg kg 1 BW once daily for 4 consecutive days. The in vivo antiplasmodial activity was expressed by the dose inhibiting 50% of parasite growth (ED50). Acute toxicity was evaluated in Swiss mice after oral administration of the active fraction in series dose of 2000-8000 mg kg 1 BW. The acute toxicity was expressed by the dose leading 50% deaths (LD50). The results showed that the active fraction of G. parvifolia Miq was active against P. berghei in mice with an ED50 of 74.45 mg/kg BW/d. In addition, the active fraction was also relatively safe as expressed by the LD50 of 8.000 mg kg 1 BW.
How to cite this article:
Syamsudin , S. Wahyuono , S. Tjokrosonto and Mustofa . In vivo Antiplasmodial Activity and Acute Toxicity of the Fraction of the Garcinia parvifolia Miq. Stem Bark.
DOI: https://doi.org/10.36478/rjpharm.2007.79.83
URL: https://www.makhillpublications.co/view-article/1815-9362/rjpharm.2007.79.83