Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
The purpose of this study was to investigate the effect of pterostilbene and its effect on key enzymes of glucose metabolism. Diabetic rats were orally administered with pterostilbene (10, 20.40, 500 mg kg‾1) for 42 days fro 22nd on word everyday for 42 day viz day 63 on glucose was determined. Administration of pterostilbene at 40 mg kg‾1 significantly decreases plasma glucose. Based on these data, the higher dose, 40 mg kg‾1 pterostilbene, was selected for further evaluation. Administration of pterostilbene for 42 dys on glucose, insulin levels and hepatic enzymes in normal and streptozotocin (STZ)-high fructose diet (HFD)-induced diabetic rats. A significant decrease in glucose and significant increase in plasma insulin levels were observed in normal and diabetic rats treated with pterostilbene. Treatment with pterostilbene resulted in a significant reduction of glycosylated hemoglobin and an increase in total hemoglobin level. The activities of the hepatic enzymes such as hexokinase was significantly increased whereas, glucose-6-phosphatase, fructose-1, 6-bisphosphatase were significantly decreased by the administration of pterostilbene in diabetic rats. A comparison was made between the action of pterostilbene and the antidiabetic drug metformin.
How to cite this article:
Payal V. Patel, Disha Chouhan and Rajesh Mujariya. Review on Effect of Pterostilbene on Hepatic Keyenzymes of Glucose Metabolism.
DOI: https://doi.org/10.36478/rjp.2020.58.70
URL: https://www.makhillpublications.co/view-article/1815-9362/rjp.2020.58.70