Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
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Comparative Study of Prophylactic Efficacy of Ondansetron and Palonosetron for Ponv in Patients Undergoing Modified Radical Mastectomy Under General Anaesthesia
Bhairavi Nikhil Baljekar and Anjali Pingle
Page: 1-5 | Received 31 Dec 2023, Published online: 12 Feb 2024
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Abstract
The syndrome of nausea, retching and vomiting is collectively called Post Operative Nausea and Vomiting (PONV). PONV is also one of the most common causes of patient dissatisfaction after anaesthesia, with reported incidences of up to 30% in all post‐surgical patients and up to 80% in high‐risk patients. The present study was aimed at comparing prophylactic efficacy of Ondansetron and Palonosetron for PONV in patients undergoing modified radical mastectomy under general anaesthesia. Present study was prospective, randomized, double blinded study conducted in female patients, allocated to group O (received ondansetron 8 mg i.v. as prophylaxis prior to induction) and group P (received palonosetron 0.075 mg i.v. as prophylaxis prior to induction). The study population was equally divided into two groups each containing 93 patients. Age, Weight, Duration of surgery (min) and ASA grade (I/II) were comparable in both groups and difference was not significant statistically. Other characteristics such as history of receiving chemotherapy, h/o PONV and h/o motion sickness were comparable in both groups and difference was not significant statistically. (p>0.05) The two groups are comparable for the incidence of nausea, retching and vomiting in the 0‐2, 2‐6 and 6‐24 hour postoperative period and difference was not significant statistically. (p>0.05). In our study, none of the patients had PONV in the 24– 72 hour period. The most frequent side effect was headache (3.76%), followed by headache with constipation (0.54%), constipation(0.54%) and giddiness (0.54%). Both the groups were comparable with respect to side effects, (p 0.534). The prophylactic efficacy of ondansetron and palonosetron as prophylaxis prior to induction, is comparable for PONV after breast surgery. The need for rescue antiemetic is comparable for the two drugs.
How to cite this article:
Bhairavi Nikhil Baljekar and Anjali Pingle. Comparative Study of Prophylactic Efficacy of Ondansetron and Palonosetron for Ponv in Patients Undergoing Modified Radical Mastectomy Under General Anaesthesia.
DOI: https://doi.org/10.36478/10.59218/makrjp.2023.3.1.5
URL: https://www.makhillpublications.co/view-article/1815-9362/10.59218/makrjp.2023.3.1.5