Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
Rheumatic valvular heart disease is a long term sequelae of rheumatic fever worldwide and the latter is the most common cause. Prevalence of rheumatic valvular heart disease is 15.7 million persons worldwide. To assess and compare the efficacy of Acenocoumarol and Warfarin in valve replaced patients with Rheumatic heart disease. To assess and compare the safety and tolerability of Acenocoumarol and Warfarin in valve replaced patients with Rheumatic heart disease. The present study was a randomized, prospective, open label, comparative study. This study was conducted from January 2018 to December 2018 at Department of Pharmacology in collaboration with Department of Cardio‐Thoracic and Vascular Surgery (CTVS) at Institute of Post Graduate Medical Education and Research, Kolkata. RHD primarily affects the mitral valve (in approximately 2/3 rd of patients), as in this study, total 46.66% cases of MS, MR and MVR operations were noted due to RHD. As total 77.27% ADRs (100% in Acenocoumarol group and 58.33% in Warfarin group) were definitely preventable, precaution must be taken to prevent ADRs. As total 77.27% ADRs (100% in Acenocoumarol group and 58.33% in Warfarin group) were mild, it is important to follow‐up for ADRs to prevent further complications. The study therefore concluded that Acenocoumarol and Warfarin are equally efficacious. After comparing overall safety in both groups or after comparing overall adverse drug reaction (ADRs) between Acenocoumarol group and Warfarin group, it is observed that according to severity of ADRs, Acenocoumarol is better and safer than Warfarin. This study showed that Vitamin K antagonists (VKAs) like Acenocoumarol or Warfarin must be administered as oral anticoagulants, after heart valve replacement surgery, in post‐operative patients and both Acenocoumarol and Warfarin are equally effective in maintaining INR within therapeutic target range.
How to cite this article:
Sandeep Vihan and Rahul Agarwal. A Comparison of the Efficacy and Safety of Acenocoumarol and Warfarin in Valve Replaced
Patients with Rheumatic Heart Disease.
DOI: https://doi.org/10.36478/10.59218/makrjp.2023.2.10.17
URL: https://www.makhillpublications.co/view-article/1815-9362/10.59218/makrjp.2023.2.10.17