Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
One of the most prevalent comorbidities that may afflict psoriatic people is cardiovascular disease (CVD). Both psoriasis and CVD have both exogenous and endogenous variables contributing to their genesis and progression. There may be a hereditary component between the two conditions, but there are still some unanswered questions about the frequency of CVD in psoriatic individuals. Dysbiosis of the gut microbiota has recently been linked to the onset and progression of both illnesses. For each case, fecal samples were obtained within 24 h of production and were stored at‐20 BC in sterile containers until use. To reduce possible biases due to environmental effects on the microbiome composition, the study enrolled Caucasian individuals from the same geographic area all of whom had a similar diet and had not received probiotics or antibiotics in the 6 months prior to recruitment. Patients with coronary artery disease have previously been found to have an elevated abundance of Proteobacteria. Our results imply that a greater Proteobacteria abundance in psoriatic patients with CVD may increase the production of inflammatory cytokines, which in turn may contribute to inflammatory processes associated with both psoriasis and CVD. Furthermore, we found that psoriatic patients with CVD had considerably greater proportions of the species Bacteroides ovatus, the genera Coprococcus and Phascolarctobacterium and the family Barne‐siellaceae. When the gut microbiome makeup of patients with and without CVD was compared, it was shown that those with the disease had increased prevalence of Phascolarctobacterium and Barnesiellaceae. Barnesiellaceae abundance levels were similar to those of patients without CVD in those receiving biologic therapy among patients with CVD. Overall, our results point to a possible connection between gut microbiome dysbiosis and the co‐occurrence of psoriasis and CVD. They also imply that treatment approaches may be able to restore intestinal symbiosis, which could enhance the clinical management of psoriasis and its related comorbidities.
How to cite this article:
R. Aashish and Gailin B. Sebastian. The Relationship Between Gut Microbiome Composition and Cardiovascular Risk in Obese Patients: A Cross‐Sectional Study.
DOI: https://doi.org/10.36478/10.36478/makrjp.2024.3.18.22
URL: https://www.makhillpublications.co/view-article/1815-9362/10.36478/makrjp.2024.3.18.22