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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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The Status of Hepatitis G/C Virus among HIV Positive Patients and Effects of GBV-C on the Progress of HIV Infection

Rouhi Afkari, Abdollah Taheri, Yaghoob Delkhosh, Eghbal Sekhavati and Aliyar Pirouzi
Page: 91-96 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/rjmsci.2016.91.96

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Abstract

Individuals infected with the Human Immunodeficiency Virus (HIV) are often co-infected with other pathogens in particular hepatitis viruses. HCV and GBV-C are blood-borne viruses that are highly prevalent among HIV/AIDS patients. The aim of this study was to evaluate the presence of hepatitis G virus (GBV-C) among HIV positive patients and its effect on the progress of HIV disease. One hundred and fifty HIV infected patients (92 men and 58 women) were included in this study. Patients were categorized into four different high-risk groups: intravenous drug users (n = 48), hemophiliacs (n = 45), homosexuals (n = 32) and heterosexuals (n = 25). RNA was extracted from 100 μL of serum or plasma using RNX plus kit. Reverse Transcription Polymerase Chain Reaction (RT-PCR) and nested PCR were used to detect GBV-C-RNA and HCV-RNA. GBV-C-RNA and HCV-RNA were found in 26.66 and 30% of patients, respectively. The prevalence of GBV-C for intravenous drug users, hemophiliacs, homosexuals, heterosexuals those with history of kidney disease and patients with a history of liver disease was 31.25, 28.88, 21.88, 20, 28.58 and 25%, respectively. Data show that within 4 years, CD+4 cell counts increased from 398-502 cells/mm3 while HIV-RNA load decreased to 2.1±0.7 log10 copies/mL and HGV-RNA load increased to 2.5±2.08 log10 copies/mL. The prevalence of GBV-C and HCV in HIV infection variy in different groups. Our study shows a significant relationship between co-infection with GBV-C and HIV since it slows the progression of HIV and liver diseases in 4 years after being infected.

How to cite this article:

Rouhi Afkari, Abdollah Taheri, Yaghoob Delkhosh, Eghbal Sekhavati and Aliyar Pirouzi. The Status of Hepatitis G/C Virus among HIV Positive Patients and Effects of GBV-C on the Progress of HIV Infection.
DOI: https://doi.org/10.36478/rjmsci.2016.91.96
URL: https://www.makhillpublications.co/view-article/1815-9346/rjmsci.2016.91.96