Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Changes in Some Biochemical Parameters of Kidney Functions in Rats Co-Administered with Chloroquine and Aspirin
H.U. Nwanjo , N.J.C. Okolie , G. Oze , M.C. Okafor , D. Nwosu , C. Ajero B. Anyaehie , G.C. Uloneme , C.J. Njoku and P. Nwamkpa
Page: 106-109 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
This study was done to establish the effects of co-administration of chloroquine with aspirin on kidney function. We monitored renal parameters such as urea, creatinine and electrolytes. The experimental animals were divided into 4 groups. Group 1 received only food and water (control). Group 2-4 received in addition to food and water either single dose with aspirin (8 mg kg 1 body weight day 1), chloroquine phosphate (5 mg kg 1 body weight day 1) or combined therapy of chloroquine and aspirin for 8 days. The chloroquine-treated group showed a significant increase in mean serum urea and creatinine levels (p< 0.05) and significant decrease in mean serum sodium and potassium levels (p< 0.05) when compared with the corresponding values of the control group. This study also revealed that co-administration of chloroquine and aspirin caused a more pronounced decrease in serum sodium and potassium levels. The results of the study suggest that acute administration of chloroquine may affect kidney function, more so when co-administered with aspirin; two drugs sometimes combined in the treatment of malaria in a malaria endemic country such as Nigeria.
How to cite this article:
H.U. Nwanjo , N.J.C. Okolie , G. Oze , M.C. Okafor , D. Nwosu , C. Ajero B. Anyaehie , G.C. Uloneme , C.J. Njoku and P. Nwamkpa . Changes in Some Biochemical Parameters of Kidney Functions in Rats Co-Administered with Chloroquine and Aspirin.
DOI: https://doi.org/10.36478/rjmsci.2007.106.109
URL: https://www.makhillpublications.co/view-article/1815-9346/rjmsci.2007.106.109