Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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A Study on Diagnosis of Helicobacter Pylori Infectionby Culture and Molecular Methods from Gastric Biopsy Specimens and Serological Assays in Patients with Peptic Ulcer Disease
Parameshwaran Unnithan and Richard Samuel
Page: 65-71 | Received 16 Mar 2025, Published online: 27 May 2025
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Abstract
H.pylori are asymptomatic and it may play an important role in the natural gasric ecosystem. H. pylori infection is more prevalent in developing countries. The production of the nitrates by bacteria acts as a factor in the causation of mild gastritis to peptic ulcers. The study was conducted with the approval from the institutional Ethical Committee, Sree mookambika institute of medical sciences .Inclusion Criteria are Adults >18 Years and Patients resenting With Clinical features of Gastric Ulcer, Duodenal Ulcer, Antral Gastritis And Gastric Carcinoma. Exclusion Criteria are Patients Who Were On Antibiotics, Proton um Inhibitors Or Helicobacter Pylori Therapy Within 1 Month prior To This Study. In the present study, among the patients with peptic ulcer disaese, Epigastric pain was the predominant symptom (86%) dyspepsia in 80%, vomiting 64%, loss of weight 22%, haematemesis in 12% and melena in 5% of cases. Similarly Epgastric pain was the predominant symptom among the patients with gastric carcinoma (89%), followed by vomiting (65%). in patients with gastric malignancies loss of weight (62%) and loss of appetite (55%) were strikingly high when compared with the patients with non malignant lesions. A high preponderance of H.pylori infection was noted in patients with duodenal ulcer. The inexpensive Rapid urease test detected maximum number of cases Hence, it is a valuable screening test which could be used as an adjunct to endoscopy. HpIgG antibody assays could be employed as a useful screening assay with stringent quality control measures in place for the estimation of seroprevalence of Helicobacter pylori among the high risk population. However subsequent serum samples are required to follow up the severity of the disease.
How to cite this article:
Parameshwaran Unnithan and Richard Samuel. A Study on Diagnosis of Helicobacter Pylori Infectionby Culture and Molecular Methods from Gastric Biopsy Specimens and Serological Assays in Patients with Peptic Ulcer Disease.
DOI: https://doi.org/10.36478/makrjms.2025.4.65.71
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2025.4.65.71