Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
To evaluate the efficacy and safety of intravenous doxycycline, azithromycin and their combination in the treatment of severe scrub typhus. A review of published literature and clinical trials, including the Interest trial and other multi centric studies, was undertaken. Data were assessed for endpoints such as 28‐day mortality, fever clearance time, incidence of organopathy, pharmacokinetic profiles, side effects and transition to oral therapy. Combination therapy showed a statistically significant reduction in organopathy compared to monotherapy, though mortality and fever clearance times were similar. Doxycycline and azithromycin exhibited favorable pharmacokinetic profiles for intravenous administration and successful transition to oral therapy. Both agents demonstrated acceptable safety profiles, with side effects such as gastrointestinal disturbances and skin reactions being the most common. Intravenous doxycycline and azithromycin, particularly in combination, offer enhanced clinical benefits in managing severe scrub typhus. Further large‐scale trials are needed to optimize treatment protocols and address long‐term concerns, such as antimicrobial resistance.
How to cite this article:
M.K. Suresh and R. Felix Nitin. Intravenous Administration of Doxycycline, Azithromycin, or their Combination for Managing Severe Scrub Typhus.
DOI: https://doi.org/10.36478/makrjms.2025.3.149.153
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2025.3.149.153