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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Assessment of Serum Vitamin B12 and Homocysteine Levels in Case of Cerebrovascular Accident

Md. Alamgir Perwana, Ramprasad Atta, Dinobandhu Naga, Srabani Ghosh, Goutam Chakraborti, Joyanti Mahata Sarkar, Shreya Halder and Monoj Sharma
Page: 470-474 | Received 06 Sep 2024, Published online: 11 Sep 2024

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https://doi.org/10.36478/makrjms.2024.3.470.474

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Abstract

A stroke is characterized as "a clinical syndrome consisting of rapidly developing clinical signs of focal disturbance of cerebral function lasting more than 24 hrs or leading to death with no apparent cause other than a vascular origin" (American Heart Association, 1991). To ascertain the homocysteine and serum vitamin B12 status of individuals who have had cerebrovascular accidents (CVAs). The present study was a Hospital based observational analytical study. This Study was conducted from one and half year (December, 2022 to May, 2024) at the departments of Biochemistry and Medicine. Total 232 patients were included in this study. In the cases, 34 (29.3%) patients had Hemorrhagic and 82 (70.7%) patients had Ischemic CVA. In the cases, the mean Vitamin‐B12 value (pg mL-1) (Mean±S.D.) of patients was 395.6466±137.7770. In the controls, the mean Vitamin‐B12 value (pg mL-1) (Mean±S.D.) of subjects was 538.3621±111.8301. Level of mean Vitamin‐B12 value in cases was lower with respect to controls and was statistically significant (p<0.0001). In the cases, the mean Homocysteine value (umole L-1) (Mean±S.D.) of patients was 12.5884±9.2961. In Controls, the mean Homocysteine value (umole L-1) (Mean±S.D.) was 7.1704±0.8847. Level of mean Homocysteine value in cases was higher with respect to controls and was statistically significant (p<0.0001). In conclusion, measuring blood homocysteine and vitamin B12 levels is a critical step toward understanding potential causal factors of cerebrovascular accidents. The findings suggest a potential correlation between elevated homocysteine levels and low vitamin B12 levels and an increased risk of cerebrovascular accidents. This highlights how important it is to routinely check for these biomarkers in at‐risk individuals, since doing so allows for early intervention and management strategies to lessen the possibility of such debilitating events.

How to cite this article:

Md. Alamgir Perwana, Ramprasad Atta, Dinobandhu Naga, Srabani Ghosh, Goutam Chakraborti, Joyanti Mahata Sarkar, Shreya Halder and Monoj Sharma. Assessment of Serum Vitamin B12 and Homocysteine Levels in Case of Cerebrovascular Accident.
DOI: https://doi.org/10.36478/makrjms.2024.3.470.474
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.3.470.474