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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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An Observational Study of Changes in the Coagulation Profile of Patients Undergoing Laproscopic Cholecystectomy Using Carbondioxide Pneumoperitoneum

Idireddy Vineela, K.L. Harish, Channanna Chidamber Rao and Pradeep Kumar Komerla
Page: 993-997 | Received 13 Oct 2024, Published online: 30 Dec 2024

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https://doi.org/makrjms.2024.12.993.997

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Abstract

Onearoscopy is a widely utilized diagnostic and therapeutic procedure. It offers several advantages over traditional open surgical methods, including improved cosmetic outcomes, reduced postoperative pain, expedited hospital discharge, and a faster return to normal activities and work. Consequently, this study aimed to examine the effects of carbon dioxide pneumoperitoneum on the coagulation system in patients undergoing laparoscopic surgery (LC) and to enhance surgeons' awareness of any potential adverse effects. This prospective, time‐bound study was conducted in the Department of General Surgery at PESIMSR Hospital, Kuppam, over a period of 18 months (2022‐2024). The study sample comprised 55 participants. Inclusion criteria encompassed patients who underwent laparoscopic cholecystectomy, aged between 18 and 60 years, with gallstones and gallbladder polyps, patients with chronic cholecystitis, those in the recovery stages of acute cholecystitis, surgeries lasting between 90‐180 minutes, and patients who provided consent for participation. In this study, the mean D‐DIMER level was 0.27 ± 0.04 pg/ml prior to surgery. A significant increase in D‐DIMER levels was observed 30 minutes and 6 hours post‐surgery. Additionally, prothrombin time (PT) increased significantly 30 minutes and 6 hours after pneumoperitoneum. A significant increase in activated partial thromboplastin time (APTT) values was also noted post‐surgery. There was a notable increase in prothrombin time following pneumoperitoneum, as well as an increase in APTT after surgery. A significant rise in D‐dimer levels was also observed.

How to cite this article:

Idireddy Vineela, K.L. Harish, Channanna Chidamber Rao and Pradeep Kumar Komerla. An Observational Study of Changes in the Coagulation Profile of Patients Undergoing Laproscopic Cholecystectomy Using Carbondioxide Pneumoperitoneum.
DOI: https://doi.org/10.36478/makrjms.2024.12.993.997
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.993.997