Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
72
Views
0
Downloads
A Prospective Randomized Controlled Study Comparing Intrathecal Magnesium Sulfate Versus Fentanyl Citrate as An Adjuvant to 0.5% Bupivacaine
Yedama Poojitha, Bathenapatla Srikanth Reddy, V. Koyee Mohan and Hassaan Muhammed
Page: 939-943 | Received 16 Oct 2024, Published online: 31 Dec 2024
Full Text Reference XML File PDF File
Abstract
Spinal anaesthesia is a commonly used regional anaesthesia treatment that is appropriate for a variety of surgical operations due to its substantial sensory and motor blockage. With several benefits like quick onset, efficient surgical anaesthesia, and extended post‐operative analgesia, spinal anaesthesia has changed dramatically since August Bier used it in a clinical setting for the first time in 1898. Comparing the effectiveness of intrathecal magnesium sulphate and fentanyl citrate as an adjuvant to 0.5% hyperbaric bupivacaine in spinal anaesthesia for infraumbilical procedures is the goal of this prospective randomised controlled research. This study aims to offer important insights into the best adjuvant option for enhancing post‐operative pain management in spinal anaesthesia by assessing factors such the onset and duration of sensory and motor blocking, the length of analgesia, and related haemodynamic alterations. The study was carried out at Kuppam's PESIMSR Hospital. The study was carried out between September 2023 and February 2025, a period of 18 months. The study comprised patients receiving infraumbilical operations. The method of purposive sampling was applied. The study involved ninety patients in all. The inclusion criteria taken into account in this research are ASA I and ASA II status, patients undergoing infraumbilical procedures, patients between the ages of 18 and 60, and surgeries lasting less than two hours. Patients who refuse to participate, have bleeding issues, or take anticoagulants are excluded. disorders of the nervous system or musculoskeletal system, local infection at the injection site, existence of cardiovascular disease, hepatic or renal illness, or both. There was no significant difference in the incidence of bradycardia or intraoperative hypotension across the groups. Bradycardia was observed in 6.7% and 4.4% of fentanyl and magnesium receivers, respectively (p = 0.55), while hypotension was observed in 17.8% and 8.9% of recipients (p = 0.21). These results are in line with those of Gupta et al. and Boules et al., who neither found any statistically significant haemodynamic deterioration in the fentanyl or magnesium groups. When used as adjuvants to bupivacaine, magnesium sulphate and fentanyl both successfully improved the quality of spinal anaesthesia. Although fentanyl produced an acceptable level of analgesia and a quicker start of block, it was linked to a higher frequency of opioid‐related adverse events. In contrast, magnesium sulphate has a better safety record, a longer duration of postoperative analgesia, and a slower onset.
How to cite this article:
Yedama Poojitha, Bathenapatla Srikanth Reddy, V. Koyee Mohan and Hassaan Muhammed. A Prospective Randomized Controlled Study Comparing Intrathecal Magnesium Sulfate Versus Fentanyl Citrate as An Adjuvant to 0.5% Bupivacaine.
DOI: https://doi.org/10.36478/makrjms.2024.12.939.943
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.939.943