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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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To Evaluate the Association of Various Parameters Associated with Severity of Acute Pancreatitis‐A Prospective Observational Study

P.R. Thatchanamoorthy, S. Pruthvi Raj, Channanna Chidamber Rao and Kummara Gnana Venkata Sai Mounika
Page: 900-904 | Received 20 Oct 2024, Published online: 31 Dec 2024

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https://doi.org/makrjms.2024.12.900.904

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Abstract

Acute pancreatitis (AP) presents with a broad spectrum of clinical manifestations and severity. While the majority of patients experience a moderate course that resolves spontaneously, approximately 20% of cases progress to a severe necrotizing form, characterized by organ failure and mortality rates ranging from 10% to 50%. A critical component of acute pancreatitis management is the accurate assessment of its severity. Current scoring methods often fail to identify individuals with severe illness, and the cost associated with generating these scores is substantial. Consequently, this study focused on identifying individual characteristics that may serve as early indicators of severe illness. Given the high incidence of acute pancreatitis admissions in this region, this topic was selected for investigation. The objective of this study was to examine the factors associated with the severity of acute pancreatitis. This prospective observational study aimed to evaluate the association of clinical, biochemical, and radiological parameters with the severity of acute pancreatitis. Conducted from August 2023 to September 2024 at the general surgery department of the PES Institute of Medical Sciences and Research in Andhra Pradesh, the study included eighty consecutive patients aged 18 to 68 years who presented with symptoms of acute pancreatitis. Diagnosis was based on clinical signs, biochemical markers, and radiological findings. The majority of cases (37.5%) were observed in individuals aged 40–50 years. In our study, 56 patients (70%) had mild acute pancreatitis, 15 (18.5%) had moderately severe acute pancreatitis, and 9 (11.25%) had severe acute pancreatitis. Alcohol consumption was identified as the cause in 56 patients (70%), while gallstone pancreatitis accounted for 14 cases (17.5%). Among the study population, 50 patients (62.5%) had diabetes, 32 (40%) had hypertension, and 40 (50%) had dyslipidemia, with diabetes mellitus being the most prevalent comorbidity. In terms of body mass index (BMI), 38 cases (47.5%) had a BMI between 18.5 and 24.9, 8 (10%) had a BMI over 30, and 34 (42.5%) had a BMI between 18.5 and 19.9. Notably, 56 participants (70%) reported a history of alcohol consumption. Effective treatment should not rely solely on a single grading system. Diagnosis of pancreatitis should be based on clinical, laboratory, and radiological assessments, with prompt initiation of vigorous crystalloid resuscitation and intensive care monitoring.

How to cite this article:

P.R. Thatchanamoorthy, S. Pruthvi Raj, Channanna Chidamber Rao and Kummara Gnana Venkata Sai Mounika. To Evaluate the Association of Various Parameters Associated with Severity of Acute Pancreatitis‐A Prospective Observational Study.
DOI: https://doi.org/10.36478/makrjms.2024.12.900.904
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.900.904